Antioxidant therapy in idiopathic pulmonary fibrosis: hope is kindled
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چکیده
منابع مشابه
Antioxidant therapy in idiopathic pulmonary fibrosis: hope is kindled.
T he new American Thoracic Society/European Respiratory Society classification of the idiopathic interstitial pneumonias [1] has redefined entities previously grouped as ‘‘idiopathic pulmonary fibrosis’’ (IPF), but carrying a much better prognosis than that disorder. As a result, the core entity of IPF is now diagnosed with greater precision than ever before. The outcome has worsened correspond...
متن کاملAntioxidant therapy for idiopathic pulmonary fibrosis. A promising therapeutic prospect.
pulmonary fibrosis (IPF) is a chronic progressive disorder of the lung of unknown etiol-ogy. Originally, it was speculated that IPF resulted from an unremitting inflammatory response to an exogenous insult, culminating in progressive fibrosis. By targeting the inflammatory response, the belief was that the fibrosis could be limited and/or prevented. However, a growing body of evidence suggests ...
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Currently, there are no approved pharmacological treatments for the management of patients with idiopathic pulmonary fibrosis (IPF) in the USA or Europe. Pirfenidone is an orally bio-available small molecule that exhibits antifibrotic and anti-inflammatory properties in a variety of in vitro and animal models. Pirfenidone has been evaluated in four randomised, double-blind, placebo-controlled c...
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Idiopathic pulmonary fibrosis (IPF) is a progressive disorder with poor prognosis. Response to treatment is infrequent and the use of immunosuppressive agents other than corticosteroids is the subject of ongoing discussion because of uncertain efficacy and side-effects. To determine the efficacy and safety of cyclophosphamide pulse therapy in IPF, this study retrospectively analysed 18 patients...
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1 Nathan RA, Yancey SW, Waitkus-Edwards K, et al. Fluticasone propionate nasal spray is superior to montelukast for allergic rhinitis while neither affects overall asthma control. Chest 2005; 128:1910–1920 2 Robinson DS, Campbell D, Barnes PJ. Addition of leukotriene antagonists to therapy in chronic persistent asthma: a randomised double-blind placebo-controlled trial. Lancet 2001; 357:2007–20...
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ژورنال
عنوان ژورنال: European Respiratory Journal
سال: 2006
ISSN: 0903-1936,1399-3003
DOI: 10.1183/09031936.06.00010006